William G Wierda Selected Research

B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)

1/2022	STAT3 Activates the Pentraxin 3 Gene in Chronic Lymphocytic Leukemia Cells.
1/2022	The cure of leukemia through the optimist's prism.
1/2022	Efficacy and safety in a 4-year follow-up of the ELEVATE-TN study comparing acalabrutinib with or without obinutuzumab versus obinutuzumab plus chlorambucil in treatment-naïve chronic lymphocytic leukemia.
1/2022	Vecabrutinib inhibits B-cell receptor signal transduction in chronic lymphocytic leukemia cell types with wild-type or mutant Bruton tyrosine kinase.
1/2022	Cyclin-dependent kinase inhibitor fadraciclib (CYC065) depletes anti-apoptotic protein and synergizes with venetoclax in primary chronic lymphocytic leukemia cells.
1/2022	Targeting Mcl-1 by AMG-176 During Ibrutinib and Venetoclax Therapy in Chronic Lymphocytic Leukemia.
1/2022	Pirtobrutinib inhibits wild-type and mutant Bruton's tyrosine kinase-mediated signaling in chronic lymphocytic leukemia.
1/2022	Phase 1 TRANSCEND CLL 004 study of lisocabtagene maraleucel in patients with relapsed/refractory CLL or SLL.
1/2022	TP53-altered chronic lymphocytic leukemia treated with firstline Bruton's tyrosine kinase inhibitor-based therapy: A retrospective analysis.
12/2021	The TKI Era in Chronic Leukemias.

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William G Wierda Research Topics

Disease

148	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2022 - 06/2003
46	Neoplasms (Cancer) 01/2022 - 06/2003
24	Leukemia 01/2022 - 04/2004
16	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 06/2003
16	Disease Progression 12/2021 - 05/2005
11	Hematologic Neoplasms (Hematological Malignancy) 12/2021 - 04/2004
10	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2022 - 02/2003
9	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2022 - 02/2006
8	Lymphoma (Lymphomas) 02/2020 - 12/2003
7	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022 - 04/2006
7	Residual Neoplasm 12/2021 - 01/2011
7	Infections 01/2020 - 09/2003
7	Lymphadenopathy 11/2019 - 10/2007
6	Diarrhea 01/2021 - 02/2008
6	Lymphocytosis 01/2020 - 09/2011
6	B-Cell Lymphoma (Lymphoma, B Cell) 08/2019 - 06/2010
5	Tumor Lysis Syndrome 01/2022 - 01/2019
5	Philadelphia Chromosome 01/2022 - 02/2003
4	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2021 - 03/2017
4	Cytopenia 01/2021 - 09/2011
3	Exanthema (Rash) 01/2021 - 11/2017
3	Nausea 01/2020 - 02/2008
3	Trisomy (Trisomies) 07/2015 - 04/2008
2	Hairy Cell Leukemia 01/2022 - 06/2006
2	Acute Promyelocytic Leukemia 01/2022 - 11/2015
2	Hemorrhage 01/2021 - 12/2015
2	Thrombocytopenia (Thrombopenia) 01/2021 - 02/2008
2	Neutropenia 01/2021 - 01/2020
2	Headache (Headaches) 01/2021 - 01/2021
2	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 01/2021 - 01/2021
2	Second Primary Neoplasms (Neoplasms, Second) 05/2019 - 07/2015
2	Fatigue 01/2018 - 02/2008

Drug/Important Bio-Agent (IBA)

34	ibrutinibIBA 01/2022 - 02/2012
29	fludarabineIBA 01/2022 - 06/2004
27	Rituximab (Mabthera)FDA Link 01/2022 - 04/2006
23	Agammaglobulinaemia Tyrosine KinaseIBA 01/2022 - 02/2012
22	venetoclaxIBA 01/2022 - 08/2015
15	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2004
14	Cyclophosphamide (Cytoxan)FDA LinkGeneric 12/2021 - 04/2009
12	Lenalidomide (CC 5013)FDA Link 01/2019 - 06/2008
9	Tyrosine Kinase InhibitorsIBA 01/2022 - 12/2007
9	acalabrutinibIBA 01/2022 - 01/2016
9	Phosphotransferases (Kinase)IBA 01/2021 - 12/2007
9	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA 08/2014 - 06/2003
8	ofatumumab FDA Link 01/2020 - 04/2010
8	Alemtuzumab (Campath)FDA Link 11/2011 - 12/2003
7	Monoclonal AntibodiesIBA 02/2020 - 12/2003
7	idelalisibIBA 11/2019 - 09/2011
6	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2022 - 01/2008
6	Biological ProductsIBA 11/2019 - 02/2006
6	Immunoglobulins (Immunoglobulin)IBA 04/2009 - 12/2003
5	Pharmaceutical PreparationsIBA 01/2022 - 02/2008
5	Biomarkers (Surrogate Marker)IBA 10/2021 - 09/2007
5	Imatinib Mesylate (Gleevec)FDA Link 09/2009 - 04/2004
4	obinutuzumabIBA 01/2022 - 07/2015
4	Chimeric Antigen ReceptorsIBA 01/2021 - 01/2015
4	Histone Deacetylase InhibitorsIBA 12/2017 - 11/2006
3	Apoptosis Regulatory ProteinsIBA 01/2022 - 05/2005
3	NucleotidesIBA 01/2022 - 02/2012
3	Dasatinib (BMS 354825)FDA Link 01/2022 - 12/2007
3	Chlorambucil (Leukeran)FDA Link 01/2022 - 07/2015
3	NucleosidesIBA 01/2022 - 09/2005
3	Azacitidine (5 Azacytidine)FDA Link 01/2021 - 10/2007
3	Immunoglobulin Variable RegionIBA 01/2020 - 04/2009
3	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2020 - 07/2015
3	Alkylating AgentsIBA 03/2017 - 04/2009
3	MicroRNAs (MicroRNA)IBA 06/2015 - 06/2013
3	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2013 - 05/2009
3	Messenger RNA (mRNA)IBA 04/2011 - 06/2005
2	blinatumomabIBA 01/2022 - 01/2022
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2022 - 05/2009
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2022 - 10/2007
2	vecabrutinibIBA 01/2022 - 01/2022
2	Core Binding Factors (Core-Binding Factor)IBA 01/2022 - 11/2015
2	pirtobrutinibIBA 01/2022 - 01/2021
2	tapotoclaxIBA 01/2022 - 01/2020
2	Cladribine FDA LinkGeneric 01/2022 - 06/2006
2	Adenosine Triphosphate (ATP)IBA 01/2022 - 06/2005
2	ponatinibIBA 01/2022 - 01/2021
2	Indicators and Reagents (Reagents)IBA 11/2021 - 06/2003
2	Decitabine FDA Link 01/2021 - 11/2006
2	ublituximabIBA 11/2019 - 02/2019
2	umbralisibIBA 11/2019 - 02/2019
2	Purine NucleosidesIBA 01/2018 - 11/2017
2	Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric 01/2018 - 11/2017
2	Clofarabine (Clolar)FDA Link 01/2018 - 11/2017
2	Transaminases (Aminotransferases)IBA 11/2017 - 12/2015
2	Bendamustine Hydrochloride FDA Link 03/2017 - 06/2014
2	carfilzomibIBA 09/2016 - 01/2015
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 06/2015 - 07/2008
2	Proteasome InhibitorsIBA 01/2015 - 04/2009
2	LigandsIBA 02/2014 - 11/2007
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 10/2013 - 01/2008

Therapy/Procedure

64	Therapeutics 01/2022 - 02/2003
10	Drug Therapy (Chemotherapy) 01/2022 - 12/2003
5	Salvage Therapy 01/2021 - 10/2007
4	Immunotherapy 07/2021 - 04/2010
4	Aftercare (After-Treatment) 01/2019 - 02/2003
2	Transplantation 01/2021 - 05/2015
2	Stem Cell Transplantation 05/2017 - 05/2015